Mp35-09 Municipal Drinking Water Constituents and Bladder Cancer Incidence: A Water-Wide Association Study (Wwas)

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation II (MP35)1 May 2024MP35-09 MUNICIPAL DRINKING WATER CONSTITUENTS AND BLADDER CANCER INCIDENCE: A WATER-WIDE ASSOCIATION STUDY (WWAS) Simon John Christoph Soerensen, Christian Jackson, David H. Rehkopf, Eila C. Skinner, Kris B. Prado, Benjamin I. Chung, and John T. Leppert Simon John Christoph SoerensenSimon John Christoph Soerensen , Christian JacksonChristian Jackson , David H. RehkopfDavid H. Rehkopf , Eila C. SkinnerEila C. Skinner , Kris B. PradoKris B. Prado , Benjamin I. ChungBenjamin I. Chung , and John T. LeppertJohn T. Leppert View All Author Informationhttps://doi.org/10.1097/01.JU.0001009372.61513.54.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Bladder cancer is one of most common cancers, with an estimated 82,290 new cases in 2023 in the U.S. alone. However, there is significant geographic variability in the incidence of bladder cancer that could be due to environmental exposures, including drinking water constituents. We sought to evaluate the potential county-level associations between municipal drinking water constituents and bladder cancer incidence. METHODS: We conducted a large-scale Water-Wide Association Study (WWAS) to systematically explore the relationships between 171 drinking water constituents and bladder cancer incidence across California's 58 counties. This WWAS extracted the observed cancer cases for each county and also calculated the expected case counts based on population counts and cancer rates for specific age groups (<50, 50-64, 65-74, and 75+) for 2011-2015 and 2016-2020. We first examined all drinking water exposures measured in 2005-2009 and bladder cancer incidence measured in 2011-2015, accounting for multiple testing and relevant confounders. The replication cohort included drinking water constituents in 2010-2014 and bladder cancer incidence in 2016-2020. We identified candidate constituents that met significance criteria in both cohorts, with associations in the same direction. RESULTS: We identified associations between 19 drinking water constituents and bladder cancer incidence in both discovery and replication cohorts (Figure 1). Minerals were the most common category of drinking water constituents associated with bladder cancer incidence (7/19). The five most common haloacetic acids (HAA5) found in drinking water (and the individual components monobromoacetic acid, dibromoacetic acid, monochloroacetic acid, dichloroacetic acid, and trichloroacetic acid) were the next most common category of drinking water constituents (6/19) followed by total and individual trihalomethanes (THM) (5/19). The nitrosamine NDMA was also identified among the drinking water constituents associated with bladder cancer incidence. CONCLUSIONS: In this ecologic study, we identified drinking water constituents associated with bladder cancer incidence. Considering environmental exposures could inform public health efforts to reduce the burden of bladder cancer. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e584 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Simon John Christoph Soerensen More articles by this author Christian Jackson More articles by this author David H. Rehkopf More articles by this author Eila C. Skinner More articles by this author Kris B. Prado More articles by this author Benjamin I. Chung More articles by this author John T. Leppert More articles by this author Expand All Advertisement PDF downloadLoading ...