Mp35-01 a Polygenic Risk Score Is Associated With Risk of Bladder Cancer and Earlier Age at Diagnosis, Independent of Lifestyle Factors

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation II (MP35)1 May 2024MP35-01 A POLYGENIC RISK SCORE IS ASSOCIATED WITH RISK OF BLADDER CANCER AND EARLIER AGE AT DIAGNOSIS, INDEPENDENT OF LIFESTYLE FACTORS David J. Nusbaum, Zhuqing Shi, Annabelle Ashworth, Huy Tran, Jun Wei, Aaron S. Dahmen, Piyush K. Agarwal, Craig V. Labbate, Brian T. Helfand, and Jianfeng Xu David J. NusbaumDavid J. Nusbaum , Zhuqing ShiZhuqing Shi , Annabelle AshworthAnnabelle Ashworth , Huy TranHuy Tran , Jun WeiJun Wei , Aaron S. DahmenAaron S. Dahmen , Piyush K. AgarwalPiyush K. Agarwal , Craig V. LabbateCraig V. Labbate , Brian T. HelfandBrian T. Helfand , and Jianfeng XuJianfeng Xu View All Author Informationhttps://doi.org/10.1097/01.JU.0001009372.61513.54.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Genetic risk factors are not currently considered in clinical evaluation of patients at risk for bladder cancer. The objective of this study is to assess the independent and joint effects of genetic and lifestyle factors on the risk of developing bladder cancer and age at diagnosis. METHODS: This is a population-based cohort study of the UK Biobank, consisting of 3,373 bladder cancer cases and 481,275 controls. A polygenic risk score (PGS) was constructed and the effect of lifestyle and genetic factors on bladder cancer risk and age at diagnosis were assessed. RESULTS: The PGS was an independent predictor of the risk of incident bladder cancer diagnosis (hazard ratio HR = 1.15, 95% confidence interval CI: 1.14-1.17, p<0.001) and earlier age at diagnosis (β = -0.30, standard error (SE) = 0.02, p<0.001). Additive joint effects with body mass index (BMI) and smoking status were observed. The study is limited by lack of pathologic data and inability to generalize results to populations of non-European ancestry. CONCLUSIONS: The PGS was an independent and significant predictor of the risk of bladder cancer and earlier age at diagnosis. Joint effects were observed with smoking status and BMI. These data provide support for incorporating measures of genetic risk factors in efforts to improve early detection of bladder cancer. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e580 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information David J. Nusbaum More articles by this author Zhuqing Shi More articles by this author Annabelle Ashworth More articles by this author Huy Tran More articles by this author Jun Wei More articles by this author Aaron S. Dahmen More articles by this author Piyush K. Agarwal More articles by this author Craig V. Labbate More articles by this author Brian T. Helfand More articles by this author Jianfeng Xu More articles by this author Expand All Advertisement PDF downloadLoading ...