P-031 the Correlation of Blood Lead Levels and Nt-Probnp Levels in Indonesian Lead-Exposed Workers

Introduction Lead exposure has been recognized as a risk factor for cardiovascular disease (CVD). Due to its relevant prognostic information, N-terminal proBNP (NT-proBNP) was known as a useful biomarker in the diagnosis and management of CVD. This preliminary analytical study examines the potential correlation between blood lead levels (BLL) and serum concentrations of NT-proBNP in lead-exposed workers. Methods A cross-sectional study was conducted among 71 Indonesian male workers who were occupationally exposed to lead. Venous blood samples were collected from all study participants. The BLL was measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and serum NT-proBNP concentrations were detected with electrochemiluminescence immunoassay (ECLIA). Results A total of 46 participants were included in the analysis as 25 samples with NT-ProBNP levels <10 pg/dl were excluded from further analysis. The mean age was 42.3 (SD 9.6) years. The median of BLL and NT-proBNP were 8.42 µg/dl and 27.14 pg/dl. We found no correlation between BLL and NT-proBNP levels in our study (r = 0.088, p = 0.56). Discussion Due to the healthy nature of the sample chosen and the fact that this measurement is used to forecast cardiovascular diseases ten years in the future, a plausible association has not been found in this initial research. It is necessary to do a more thorough investigation with a wider range of participants, jobs, and ages. Conclusion Our study found that BLL was not correlated with serum NT-proBNP concentrations. Further investigation using more precise and varied data is needed.