O-163 the Investigation of the Association Between Non-Alcoholic Fatty Liver Disease and Blood Metal Concentrations With Whole Genome Types

Introduction Our study set out to explore the relationship between exposure to heavy metals and the occurrence of non-alcoholic fatty liver disease (NAFLD), an area with conflicting existing research and unexplored genetic implications. Methods and Results Leveraging a genome-wide type association study (GWAS), we aimed to identify the associated single nucleotide polymorphisms (SNPs) with these conditions. Data from 444 individuals working in metal industries and 767 people from non-metal related jobs were analyzed. The data included physical parameters, biochemical data, and the plasma concentrations of six different metals. We utilized the genomic database of Taiwan Biobank to conduct GWAS, leading to the identification of three SNPs. Further analysis, involving multivariable logistic regression and interaction study, revealed a significant association of NAFLD prevalence with only two of these SNPs: rs879304, a single-nucleotide variation in the MAGI2 gene on chromosome 7, and rs80040482, a single-nucleotide variation in the SNX19 gene on chromosome 11. We also examined 25 SNPs from various genes previously linked with NAFLD progression. However, none of these showed any significant relationship with NAFLD prevalence post multivariable logistic regression and interaction analysis. Discussion and Conclusion Our study identified certain genotypes susceptible to NAFLD under conditions of excessive copper exposure. However, further research is needed to unravel the underlying mechanism.