Key result
A genome-wide meta-analysis identified 5 potential susceptibility loci for NAFLD (GCKR, TR1B1, MAU2/TM6SF2, APOE, PNPLA3) among 778,614 participants of European ancestry.
Why the study?
Non-alcoholic fatty liver disease is a complex condition linked to chronic diseases, prompting the identification of associated genetic variants and their functional consequences.
Meta-Analysis (n=778,614)
Yes
This large genome-wide meta-analysis identifies 5 susceptibility loci for NAFLD and highlights shared genetic architecture with cardiometabolic diseases.
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May support polygenic risk scores for NAFLD; extends shared genetic architecture with cardiometabolic diseases.
Ghodsian et al. (2021) conducted a meta-analysis in Non-alcoholic fatty liver disease (NAFLD) (n=778,614). Genetic variants vs. Controls without NAFLD was evaluated on NAFLD susceptibility loci. A genome-wide meta-analysis identified 5 potential susceptibility loci for NAFLD (GCKR, TR1B1, MAU2/TM6SF2, APOE, PNPLA3) among 778,614 participants of European ancestry.
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