Key result
NAFLD in nonoverweight individuals is linked to a ~10-fold higher risk of incident CVD.
Why the study?
Does nonoverweight with NAFLD increase the risk of incident cardiovascular disease compared to nonoverweight without NAFLD in Japanese individuals?
Cohort (n=1,647)
Does nonoverweight with NAFLD increase the risk of incident cardiovascular disease compared to nonoverweight without NAFLD in Japanese individuals?
Hazard Ratio: 10.4 (95% CI 2.61–44)
Absolute Event Rate: 8.8% vs 0.6%
p-value: p=0.001
Nonoverweight individuals with NAFLD have a significantly higher risk of incident cardiovascular disease compared to those without NAFLD, highlighting the need for cardiovascular risk assessment in this specific population.
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May warrant CVD monitoring in nonoverweight NAFLD; leaves open causality and generalizability pending prospective studies.
Hashimoto et al. (2017) conducted a cohort in Nonalcoholic fatty liver disease (NAFLD) (n=1,647). Nonoverweight with NAFLD vs. Nonoverweight without NAFLD was evaluated on Incident cardiovascular disease (CVD) (HR 10.4, 95% CI 2.61-44.0, p=0.001). Nonoverweight individuals with NAFLD had a significantly higher risk of incident cardiovascular disease compared to nonoverweight individuals without NAFLD (HR 10.4; 95% CI 2.61-44.0; P=0.001).
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