Key result
In patients with non-alcoholic fatty liver disease, cardiovascular risk assessed by PROCAM, ASCVD, and QRISK scores is increased, with further increases observed in those with coexisting diabetes.
Why the study?
Non-alcoholic fatty liver disease (NAFLD) increases cardiovascular morbidity, but its usefulness as a cardiovascular disease risk factor in patients with and without diabetes needed evaluation.
Does coexisting diabetes increase cardiovascular risk scores in patients with non-alcoholic fatty liver disease?
Observational (n=80)
No
Does coexisting diabetes increase cardiovascular risk scores in patients with non-alcoholic fatty liver disease?
NAFLD patients have an increased calculated cardiovascular risk, which is further elevated in the presence of coexisting diabetes mellitus.
Objectives: Non-alcoholic fatty liver disease (NAFLD) is increasing in prevalence during present obesity pandemic. More than 25% of persons globally are believed to have non-alcoholic fatty liver disease. Many reports claim that there is an increased risk of atherosclerotic cardiovascular disease (ASCVD) among patients with non-alcoholic fatty liver disease. NAFLD is a silent disease in initial stages but progress to severe hepatic disease and increases cardiovascular morbidity in later stages, so identification and management of NAFLD are of paramount importance in preventive aspect of cardiovascular disease (CVD). Hence, the aim of this present study is to assess the risk of CVD in patients with non-alcoholic fatty liver disease in patients with and without diabetes and to evaluate usefulness of non-alcoholic fatty liver disease as a risk factor for CVD. Materials and Methods: The present study is a single-center observational study and it included 81 patients with non-alcoholic fatty liver disease. Results: In these patients, cardiovascular risk is assessed by ASCVD score, PROCAM score, QRISK 3 score, and atherogenic index of plasma and compared between diabetic and non-diabetic population. The difference has been found between diabetic and non-diabetic in Procom_score, ASCVD_score, and Q-risk_score but not found in AIP_score. Conclusion: The outcome of this study is that there is an increased risk of cardio vascular disease in patients with non-alcoholic fatty liver disease and risk is further increased in patients with coexisting diabetes mellitus and NAFLD.
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Mellemputi et al. (2023) conducted an observational in Non-alcoholic fatty liver disease (n=80). Coexisting diabetes mellitus vs. Non-diabetic NAFLD patients was evaluated on Cardiovascular risk assessed by ASCVD, PROCAM, and QRISK 3 scores. In patients with non-alcoholic fatty liver disease, cardiovascular risk assessed by PROCAM, ASCVD, and QRISK scores is increased, with further increases observed in those with coexisting diabetes.
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