February 13, 2006Diabetic Medicine
Increased prevalence of cardiovascular disease in Type 2 diabetic patients with non‐alcoholic fatty liver disease
Why the study?
Is non-alcoholic fatty liver disease independently associated with an increased prevalence of cardiovascular disease in patients with Type 2 diabetes?
Population
800 Type 2 diabetic patients
Comparison
Presence of non-alcoholic fatty liver disease vs Absence of non-alcoholic fatty liver disease
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Higher CVD prevalence in T2DM with NAFLD is not independent of metabolic syndrome; confirms confounding and leaves open causal roles.
Structured PICO
Is non-alcoholic fatty liver disease independently associated with an increased prevalence of cardiovascular disease in patients with Type 2 diabetes?
P
Population
800 Type 2 diabetic patients (400 with non-alcoholic fatty liver disease [NAFLD] and 400 without NAFLD matched for age and sex)
I
Intervention
Presence of non-alcoholic fatty liver disease (NAFLD)
C
Comparator
Absence of non-alcoholic fatty liver disease (NAFLD)
O
Outcome
Prevalent cardiovascular disease (CVD), including coronary, cerebrovascular, and peripheral vascular diseasehard clinical
Type 2 diabetic patients with NAFLD have a higher prevalence of cardiovascular disease, but this association appears to be driven by the co-occurrence of metabolic syndrome rather than NAFLD independently.
Cite This Study
Targher et al. (2006) studied this question.