In vitro anticancer activity of root bark of Mallotus philippensis (Lam.) Muell. Arg. on cervical cancer cell line

One of the critically endangered but medicinally significant plants utilised in traditional medicine is Mallotus philippensis (Lam.)Muell.Arg., a member of the Euphorbiaceae family that has good potential for cultivation.TLC, GC-MS, anticancer activity, and preliminary phytochemical screening were carried out on the plant extract in order to investigate the chemical composition and anticancer activity of M. philippenesis.The plant was also examined for an anticancer investigation utilising the HeLa cancer cell line.Numerous root extracts underwent an initial phytochemical screening procedure that revealed the presence of multiple chemical constituents.TLC was used for the initial chemical investigation, and GC-MS characterisation reveals the bioactive chemicals.The MTT test was utilised to assess the in vitro cytotoxicity of plant extract and standard cisplatin on HeLa cells.Plant extract performed better than the control.The cytotoxicity effect on HeLa cell lines was noted in the tested sample concentrations after a 48 h treatment; further research also indicated that higher drug concentrations were associa ted with greater cytotoxicity against HeLa cell lines.The ethanolic root extract of M. phillipens is exhibited a significant IC 50 concentration against HeLa cell lines, showed as 65.04 µg/ml and 4.43 µg/ml of plant extract and cisplatin, respectively.Consequently, the results of the ethanolic extract of M. philippensis root showed a considerable inhibition of cancer cells development.