Observational analysis reports dynamic von Willebrand factor alterations after stem cell grafting, suggesting ADAMTS13 cleavage predicts transplant-associated microangiopathy.
Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication of hematopoietic stem cell transplantation and is characterized by severe thrombocytopenia, hemolytic anemia, and organ dysfunction. In response to several possible triggers, dynamic multimetric change in von Willebrand factor (VWF) may contribute to inducing microthrombi in circulation in TA-TMA.
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Yamada et al. (2024) studied this question.
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