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March 1, 2009Cardiovascular & Haematological Disorders - Drug Targets

Thrombotic Microangiopathies: Towards a Pathophysiology-Based Classification

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Key result

Advances in understanding the pathophysiology of thrombotic microangiopathies allow for a more accurate molecular classification, opening perspectives for targeted therapies.

Population

Patients with Thrombotic Microangiopathies, including Thrombotic thrombocytopenic purpura and Hemolytic…

Design

Review

Authors

PCPaul CoppoDélégation Paris 5AVAgnès VeyradierDélégation Paris 5

Discussion

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Overview

May support molecular classification of thrombotic microangiopathies; leaves open targeted therapy benefits pending prospective trials.

Structured PICO

P
Population
Patients with Thrombotic Microangiopathies (TMA), including Thrombotic thrombocytopenic purpura (TTP) and Hemolytic uremic syndrome (HUS)

Improved understanding of the pathophysiology of thrombotic microangiopathies enables a more accurate molecular classification, paving the way for targeted therapies.

Cite This Study

Coppo et al. (2009) conducted a review in Thrombotic Microangiopathies. Advances in understanding the pathophysiology of thrombotic microangiopathies allow for a more accurate molecular classification, opening perspectives for targeted therapies.

synapsesocial.com/papers/6a859f434f2eb4dbc91e65a2https://doi.org/10.2174/187152909787581318
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Also Consider

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  1. 1Acute myocardial infarction in thrombotic microangiopathies—clinical characteristics, risk factors and outcome2006 · 116 citations
  2. 2Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome2004 · 338 citations
  3. 3Regional UK TTP Registry: correlation with laboratory ADAMTS 13 analysis and clinical features2008 · 381 citations
  4. 4CNS Manifestations of the Hemolytic-Uremic Syndrome1980 · 123 citations
  5. 5ADAMTS13 activity in thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients2003 · 678 citations