Analysis of Frozen Section With Paraffin Section at Tertiary Care Centre

Background: Frozen section was rst introduced by William H. Welch at John Hopkins hospital in the year 1891 for intra-operative consultation. It was further developed by Wilson and McCarty in 1905 at mayo clinic. This practice has since then evolved especially after development of cryostat in 1959. Frozen section is a multistep process involving surgical resection, preparation of slides and their microscopic examination, communicating frozen section diagnosis to surgeon and processing the remaining tissue for further work up. The main Aim and objective: purpose of frozen section is provide rapid diagnosis to guide intra or peri-operative patient management. Comparison of frozen diagnosis and nal histopathology diagnosis aids in assessing the degree of diagnostic accuracy. This study was carried Materials and Methods: 50 cases. The gross specimen were cut into thin slices and examined. Section were taken from abnormal, suspected areas or from rm lesions and placed in mounting medium (OCT). Overall concordance rate of 96% was obtained for frozen section & histopathological d Results: iagnosis with 87.5% accuracy in ovary and 66.66 % accuracy in GIT & 100% accuracy in breast, tongue, thyroid, appendix, gall bladder, endometrium, skin, brain and retroperitoneum. : Frozen section is a reliable and accurate intra operative consultation modality Conclusion , but one needs to be aware of its indication and limitation. Better communication of pathologist and surgeon will reduce interpretation error leading to high diagnostic accuracy & new improved standard of care.