Diagnostic Utility of Anti-Cyclic Citrullinated Peptide Antibodies in Comparison With Rheumatoid Factor, C-Reactive Protein and Erythrocyte Sedimentation Rate in Rheumatoid Arthritis Patients

Background: Rheumatoid arthritis (RA) is the most common inammatory joint disorder in adults and is characterized by chronic synovitis, systemic inammation and autoantibody production. Rheumatoid factor (RF) and Anti cyclic citrullinated peptide antibodies (ACPA) are commonly found in the serum of this patients and are therefore established diagnostic markers. Objectives:To compare diagnostic utility of ACPA in comparison with Rheumatoid factor, CRPand Erythrocyte sedimentation rate (ESR). Methodology:Retrospective and prospective case control study was conducted in 80 patients and 20 control group at tertiary care center. Results: Anti-CCP was 92.5% positive in case group and 100% negative in control group with p value<0.00001 which was statistically signicant. Correlation between Anti-CCPand RF showed signicant titers with p value <0.001. Results were variable with respect to CRP and ESR. Conclusion: Anti-CCP is more specic than the other parameters for the diagnosis of RA.