Azithromycin Instead of Erythromycin for Prophylaxis in Preterm Pre-Labor Rupture of Membranes

Background: The pre-labor rupture of membranes before 37 0/7 weeks of gestation is referred as preterm premature rupture of membranes and complicates around 3% of pregnancies. Traditionally antibiotics have been shown to prolong pregnancy, reduce maternal and neonatal infections, and reduce fetal morbidity. A seven-day course of therapy with intravenous penicillin along with erythromycin base is usually recommended in preterm PROM at less than 34 weeks of gestation. Recently many institutions have promoted the use of azithromycin to replace erythromycin, due to the comparable effectiveness, low prole of side effects, and the lower cost of azithromycin compared to erythromycin. In this article, the rationale of replacing azithromycin in place of erythromycin for managing women with pregnancies with complicated pre-labor rupture of membranes was reviewed. Conclusion:It can be concluded that azithromycin can be considered a safe alternative to erythromycin for prophylaxis in preterm pre-labor rupture of membra