What does this research mean for the field?

In expectantly managed preterm prelabor rupture of membranes (PPROM) before 35 weeks, an expanded antibiotic regimen of ampicillin, ceftriaxone, and clarithromycin is independently associated with a reduction in clinical chorioamnionitis compared to the standard ampicillin-erythromycin regimen. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare maternal and neonatal outcomes in women with preterm prelabor rupture of membranes managed expectantly with ampicillin-erythromycin versus an expanded ampicillin-ceftriaxone-clarithromycin regimen.

September 5, 2026International Journal of Gynecology & Obstetrics

Maternal and neonatal outcomes associated with expanded antibiotic therapy in preterm prelabor rupture of membranes

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Authors

JBJuan Manuel Burgos‐LunaFundación Valle del Lili LGLaura Soto Giraldo MSMaria Alejandra Suarez-ReveloFundación Valle del Lili

Discussion

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Implication

Cohort study reveals lower maternal and neonatal infectious morbidity with expanded antibiotic therapy in preterm prelabor rupture of membranes, suggesting improved clinical protection.

Key Points

To compare maternal and neonatal outcomes in women with preterm prelabor rupture of membranes managed expectantly with ampicillin-erythromycin versus an expanded ampicillin-ceftriaxone-clarithromycin regimen.
Retrospective cohort study of 136 women with preterm prelabor rupture of membranes before 35 weeks managed expectantly between January 2019 and December 2024.
Compared standard ampicillin-erythromycin (n=64, 2019–2022) against an institutional alternative of ampicillin-ceftriaxone-clarithromycin (n=72, 2023–2024).
Evaluated maternal infectious morbidity, early-onset neonatal sepsis, and latency to delivery using restricted mean time to delivery (RMTD).
The expanded regimen significantly reduced clinical chorioamnionitis (16.7% vs. 32.8%; P=0.044), maternal sepsis (1.4% vs. 14.1%; P=0.006), postpartum endometritis (1.4% vs. 12.5%; P=0.013), and early-onset neonatal sepsis (46.5% vs. 66.1%; P=0.039).
Delivery latency was not significantly different between the expanded and standard regimens (RMTD difference 1.39 days; 95% CI: -2.40 to 5.18; P=0.471).

Cite This Study

Burgos‐Luna et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3e16b95aff0620eb0c6 https://doi.org/10.1002/ijgo.71342

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Implication

Cohort study reveals lower maternal and neonatal infectious morbidity with expanded antibiotic therapy in preterm prelabor rupture of membranes, suggesting improved clinical protection.

Maternal and neonatal outcomes associated with expanded antibiotic therapy in preterm prelabor rupture of membranes

Discussion

Member takes

Implication

Key Points

Cite This Study

Maternal and neonatal outcomes associated with expanded antibiotic therapy in preterm prelabor rupture of membranes

Discussion

Member takes

Implication

Key Points

Cite This Study

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