Deep Residual-in-Residual Model-Based PET Image Super-Resolution with Motion Blur

Positron emission tomography (PET) is a non-invasive molecular imaging technique. The limited spatial resolution of PET images, due to technological and physical imaging constraints, directly affects the precise localization and interpretation of small lesions and biological processes. The super-resolution (SR) technique aims to enhance image quality by improving spatial resolution, thereby aiding clinicians in achieving more accurate diagnoses. However, most conventional SR methods rely on idealized degradation models and fail to effectively capture both low- and high-frequency information present in medical images. For the challenging SR reconstruction of PET images exhibiting motion-induced artefacts, a degradation model that better aligns with practical scanning scenarios was designed by us. Furthermore, we proposed a PET image SR method based on the deep residual-in-residual network (DRRN), focusing on the recovery of both low- and high-frequency information. By incorporating multi-level residual connections, our approach facilitates direct feature propagation across different network levels. This design effectively mitigates the lack of feature correlation between adjacent convolutional layers in deep networks. Our proposed method surpasses benchmark methods in both full-reference and no-reference metrics and subjective visual effects across small animal PET (SAPET), phantoms, and Alzheimer’s Disease Neuroimaging Initiative (ADNI) datasets. The experimental findings confirm the remarkable efficacy of DRRN in enhancing spatial resolution and mitigating blurring in PET images. In comparison to conventional SR techniques, this method demonstrates superior proficiency in restoring low-frequency structural texture information while simultaneously maintaining high-frequency details, thus showcasing exceptional multi-frequency information fusion capabilities.