In-vitro synergistic interactions of Baicalein in combination with β-lactam antibiotics against Methicillin-resistant Staphylococcus aureus

INTRODUCTIONStaphylococcus aureus (S. aureus) is the most prevalent bacterial organism which causes the most severe form of cow mastitis and poses a significant challenge to clean milk production [1].S. aureus mastitis causes significant economic losses in terms of a sharp drop in milk revenue, elimination of superior animals, higher veterinary care expenses, and the need to replace tainted milk [2,3].Even though antibiotics are the cornerstone of treatment for S. aureus mastitis, the excessive use of proven antimicrobial agents in the management of S. aureus mastitis has culminated in a dramatic rise in the number of antibiotic-resistant