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Accelerated orthodontic tooth movement (OTM) has been widely desired because of its potential advantages, which include reduced treatment duration, enhanced posttreatment stability and reduction of adverse effects commonly associated with extended treatment periods. Recently, platelet-rich fibrin (PRF) and advanced platelet-rich fibrin (A-PRF) had potential functions in accelerating OTM and shortening treatment duration. This study was designed to examine the potency of intrasulcular injection of PRF and A-PRF in inducing transforming growth factor-β1 (TGF-β1) during OTM in rabbits. The study examined 45 rabbits (Oryctolagus cuniculus) that were randomly divided into 3 groups, each consisting of 15 animals: The untreated group (control), intrasulcular PRF injection group and A-PRF injection group. Each group was randomly divided into 5 subgroups according to the day of observation (days 0, 3, 7, 14 and 21). TGF-β1 levels during OTM were determined by enzyme-linked immunosorbent assay (ELISA). Data gathered were analyzed using the 2-way analysis of variance and post hoc Tukey’s honest significant difference (p < 0.05). The TGF-β1 levels were significantly different (p < 0.05) on the compression side. The TGF-β1 level in the A-PRF group was significantly lower than those in the PRF and control groups on days 7, 14 and 21 (p < 0.05). Decreasing TGF-β1 levels can affect the balance of osteoclastogenesis, thereby altering osteoclast production and function. PRF and A-PRF can help create a favorable environment for bone regrowth, which can help preserve bone health and accelerate OTM. HIGHLIGHTS The concentration of TGF-β1 in the A-PRF group was markedly lower than that in the PRF and control groups Reducing TGF-beta levels can affect osteoclastogenesis, modifying the differentiation and activity of osteoclasts Enhanced osteoclastogenesis on the pressure side of orthodontic tooth movements leads to accelerated orthodontic tooth movements GRAPHICAL ABSTRACT
Retnaningrum et al. (Sun,) studied this question.