Early-onset neonatal sepsis diagnosis – still a challenge after 30 years - Part 1

Despite all the advances in diagnosis and treatment, early-onset neonatal sepsis remains a serious and potentially life-threatening condition, with increased morbidity and mortality. The authors review the persistent controversies and challenges surrounding the definitions of neonatal sepsis, neonatal early- and late-onset sepsis, clinical signs and risk factors, and different approaches for identifying neonates at risk for early-onset sepsis. The impact of neonatal early-onset sepsis on short- and long-term outcomes is also resumed.