Recognizing and managing neonatal sepsis

Neonatal sepsis remains a leading cause of morbidity and mortality among newborns worldwide, despite recent advances in recognition and management. Both early-onset and late-onset sepsis present significant challenges for neonates, particularly those born prematurely or with low birth weight. The severity and progression of the condition can be influenced by factors such as the timing of exposure, the host's immune response, and the virulence of the infecting pathogen. As intrapartum screening methods, novel diagnostic studies, and targeted antibiotic management strategies continue to evolve, it is essential for the practicing provider to understand the implications of this condition and to recognize and manage it appropriately.