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June 29, 2024Open Access

Dual roles of histone H3 lysine-4 in antagonizing Polycomb group function and promoting target gene expression

Cyril S. Anyetei‐Anum Mary Leatham‐Jensen Geoffrey Fox B. Rutledge Smith Krzysztof Krajewski Brian D. Strahl Jill M. Dowen A. Gregory Matera Robert J. Duronio Daniel J. McKay

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Abstract

Tight control over cell identity gene expression is necessary for proper adult form and function. The opposing activities of Polycomb and trithorax complexes determine the ON/OFF state of targets like the Hox genes. Trithorax encodes a methyltransferase specific to histone H3 lysine-4 (H3K4). However, there is no direct evidence that H3K4 regulates Polycomb group target genes

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Cite This Study

Anyetei‐Anum et al. (2024) studied this question.

synapsesocial.com/papers/68e629b3b6db6435875bcb00 https://doi.org/10.1101/2024.06.25.600669

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genesOriginal Research · 2010 · 401 citations
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