Two efficient methods for the total synthesis of the natural diarylheptanoid 7-(4-hydroxyphenyl)-1-phenylheptan-3-one

Diarylheptanoids are compounds with an ArC7Ar structure, where two aromatic rings are connected by a seven-carbon chain.To date, over 500 structurally diverse diarylheptanoids have been isolated from nature.These compounds are generally minor secondary metabolites found in plants.Natural diarylheptanoids possess a wide range of biological activities, making their short and efficient total synthesis important for enabling further research on these substances.In this study, two efficient synthesis methods developed for the compound 7-(4-hydroxyphenyl)-1phenylheptan-3-one, which is isolated as a minor component from Alpinia officinarum, are presented.