Comparative Evaluation of Gingival Crevicular Fluid Sulfiredoxin Levels in Patients with Periodontitis Prior and after Periodontal Therapy: A Prospective Clinical Trial

1][12] Bone resorption, resulting in alveolar bone loss and eventual tooth IntroductIonChronic periodontitis (CP) is a persistent inflammatory condition influenced by the complex interaction between the host and oral microbes, damaging the periodontal tissue and subsequent loss of alveolar bone, ultimately leading to tooth loss.5][6] It entails an imbalance in the equilibrium between prooxidants and antioxidants, tilting in favor of the former and potentially causing damage to tissues.Cells inherently possess antioxidant molecules to counteract the effects of oxidative stress.Enzymatic reactions involving molecular oxygen, facilitated by various enzymes, give rise to reactive oxygen species (ROS) viz superoxide anions (O 2 -), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH -), singlet oxygen [O 2 ( 1 Δ g )], nitric oxide (NO) and hypochlorous acid (HOCl). 7Within the human body, all cells can generate ROS, with polymorphonuclear neutrophils assuming a pivotal role in the context of periodontitis.Neutrophils, serving as the first line of defense, are strategically located at sites of microbial invasion, activated by inflammatory mediators to produce heightened levels of ROS, which not only target periodontopathogens but also impact surrounding tissues. 8,9Several findings have suggested that ROS governs the formation and function of osteoclasts, 1,