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June 28, 2024Open Access

Reduced SH3RF3 may protect against Alzheimer disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

Ronak Patel Christopher L. Cardona Ellen Angeles Gunjandeep Singh Archana Ashok Andrew F. Teich Andrew A. Sproul

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Abstract

Understanding how high-risk individuals are protected from Alzheimer's disease (AD) may illuminate potential therapeutic targets. A previously identified non-coding SNP in SH3RF3/POSH2 significantly delayed disease onset in a Caribbean Hispanic cohort carrying the PSEN1

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Patel et al. (2024) studied this question.

synapsesocial.com/papers/68e62c1bb6db6435875be416 https://doi.org/10.1101/2024.06.23.600281

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