Comparison of Outcome of Metformin And Inositol on Hormonal Aspects in Women with Polycystic Ovaries: A Quasi-Experimental Study

Objective: To individually assess the role of Metformin and Inositol in dealing with hormonal problems in terms of serum Luteinizing Hormone/ Follicular stimulating hormone ratio, serum prolactin and serum progesterone in females with polycystic ovarian disease over a period of one year. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Gynaecology and Obstetrics, PAF Hospital Islamabad Pakistan, from Jul 2020 to Jul 2021. Methodology: Patients (n=80) presenting with OPD were divided into two equal groups and followed over a period of six months. Group-A was given Tab Inositol 4g once daily, and Group-B was given Tab Metformin 500 mg three times daily. Over a period of three to six months, Metformin and Inositol were used to compare biochemical parameters such as serum Luteinizing Hormone/ Follicular stimulating hormone ratio, serum prolactin, and serum progesterone. Results The results showed that Inositol has better results in terms of hormonal aspects, with a mean Luteinizing Hormone/ Follicular stimulating hormone ratio of 2.55±0.02 at 6 months. At three and six months, the mean serum prolactin and mean serum progesterone were comparable in both groups. Conclusion: Inositol has a better impact on hormonal aspects in women with polycystic ovarian disease by improving patients’ biochemical profiles.