Weekly Trelagliptin Improves Quality of Life in Type 2 Diabetic Patients of Hyderabad, Sindh, Pakistan

Introduction Type 2 diabetes is alarmingly increasing all over the globe. The oral anti diabetics are facing compliance problems, cost and limited improvement in quality of life. The DPP4 inhibitors increase incretin levels and have no chances of hypoglycemia thus improve overall quality of life. Objective To assess improvement in quality of life in type 2 diabetes mellitus, pre and post use of weekly trelagliptin attended OPD of Liaquat University Hospital Hyderabad / Jamshoro Sindh Pakistan Study Design& duration. Quasi-experimental. Study Setting; OPDs of Liaquat University Hospital Hyderabad / Jamshoro and Duration of Study; July 2023 to October 2023 Methodology: 340 patients with type 2 diabetes for at least 2 years duration, already on metformin with or without glimepiride, age limit from 25-60 years of either gender were selected by nonprobability consecutive method. All patients had under gone for estimation of BMI, HbA1c and inquired for health related quality of life by LUMHS designed questionnaire. That questionnaire was designed after searching data base. 5 items calibrated from good to poor life quality such as finance, diet, sexual active, energy level and memory. Pre and post trelagliptin weekly given for 3 months and mean of pre and post response was assessed. The change of mean > 1.3 or Rubric > 10 score signified better health related life. Reduction in HbA1c of at least ≥0.5% from the baseline and at 3 months was considered as secondary outcome achieved by weekly trelagliptin. Results; 340 patients were selected, the mean age was 47 ±4.89 years. There were 220 males (65%) and 120 (35%) males. There is a significant proportion of males aged 47-60 years (61%) compared to females (37.5%). A higher percentage of females are married (79%). Females have a slightly higher mean BMI (25 ± 1.4) compared to males (24 ± 1.2). The values indicate that males have a higher average HbA1c level 0.5 compared to females 0.3. The pre and post Trelagliptin showed the variables Finance, Diet, Energy Level, and Sexual Activity showed statistically significant differences between males and females, with P-values less than 0.05. Memory, however, does not show a significant difference. Conclusion: Weekly trelagliptin improved quality of life as well as HbA1c and it also better tolerated.