From Evidence to Practice: Denosumab in Osteoporosis and Joint Health

Osteoporosis and osteopenia are prevalent conditions in India, particularly among postmenopausal women and the elderly, leading to increased fracture risks and morbidity. Denosumab, a monoclonal antibody, demonstrates superior efficacy over other treatments in reducing fracture risk and enhancing bone mineral density (BMD). Clinical trials highlight its effectiveness in preventing periprosthetic bone loss, improving implant stability, and mitigating femoral head collapse in various conditions; combination therapies involving denosumab further amplify BMD gains and reduce fracture risk. The article reviews the efficacy and safety of denosumab in managing osteoporosis, joint replacement therapy, and avascular necrosis based on a review of clinical evidence and studies. Denosumab emerges as a cornerstone therapy for osteoporosis management, offering multifaceted benefits in fracture prevention, joint replacement therapy, and avascular necrosis.