June 27, 2024Nature CommunicationsOpen Access

Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils

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Authors

DSDharti ShantaramBoston University RHRebecca HoydThe Ohio State University ABAlecia BlaszczakNorthwestern University

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Implication

Preclinical study demonstrates visceral adipose tissue inflammation driven by gut microbiota in diet-induced obesity, suggesting neutrophil-directed therapies for metabolic disease.

Key Points

Visceral adipose tissue from subjects with obesity accumulates distinct neutrophils alongside an altered microbiome, which instigates downstream tissue inflammation.
Microbiome-depleted mice display visceral adipose tissue neutrophilia only when receiving both high-fat diet and stool transplants from donors with clinical obesity.
Gavage experiments reveal that transient neutrophil spikes precede shifts in CD4+ Th1 cells; mouse model, highlighting potential targets for insulin resistance.

Cite This Study

Shantaram et al. (2024) studied this question.

synapsesocial.com/papers/68e62ea5b6db6435875c13f2 https://doi.org/10.1038/s41467-024-48935-5

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June 27, 2024Nature CommunicationsOpen Access

Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils

View Full Paper

Ask AI

Bookmark

Authors

DSDharti ShantaramBoston University RHRebecca HoydThe Ohio State University ABAlecia BlaszczakNorthwestern University

Discussion

Member takes

Implication

Preclinical study demonstrates visceral adipose tissue inflammation driven by gut microbiota in diet-induced obesity, suggesting neutrophil-directed therapies for metabolic disease.

Key Points

Visceral adipose tissue from subjects with obesity accumulates distinct neutrophils alongside an altered microbiome, which instigates downstream tissue inflammation.
Microbiome-depleted mice display visceral adipose tissue neutrophilia only when receiving both high-fat diet and stool transplants from donors with clinical obesity.
Gavage experiments reveal that transient neutrophil spikes precede shifts in CD4+ Th1 cells; mouse model, highlighting potential targets for insulin resistance.

Cite This Study

Shantaram et al. (2024) studied this question.

synapsesocial.com/papers/68e62ea5b6db6435875c13f2 https://doi.org/10.1038/s41467-024-48935-5

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