Photocatalytic α‐Difluoroalkoxyketones Synthesis via Radical Intermolecular Alkoxylation of Difluoroenol Silyl Ethers

We present a metal‐free photocatalytic approach for the synthesis of difluoroalkoxylatedketones. This strategy involves the generation of alkoxyl radicals from pyridinium salts upon the activity of a catalytic electron‐donor‐acceptor (EDA) complex. This mild process tolerates several functional groups and can be scaled up to gram scale. Diverse products manipulations accounts for the versatility of the obtained fluorinated products, highlighting the synthetic usefulness of this method.