Cancer treatment demands innovative approaches. Azithromycin (AZM), traditionally an antibiotic, shows promise in inhibiting cancer growth due to its anti-inflammatory and senolytic properties. Beyond its antimicrobial effects, AZM disrupts mitochondrial function in cancer cells, leading to increased reactive oxygen species (ROS) and DNA damage. This disrupts cancer cell survival pathways and induces programmed cell death. AZM has shown efficacy against various cancers, including lung, breast, and ovarian cancers. Nanoparticle (NP) delivery systems are proposed to enhance AZM's therapeutic potential. NPs offer advantages like increased surface area, biocompatibility, and targeted delivery to cancer cells. This review explores strategies for AZM delivery using various nanomaterials, including polymers, carbon-based materials, lipids, and inorganic frameworks. It also discusses the potential of combining AZM with other therapies.
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Pourmadadi et al. (2024) studied this question.
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