Synthetic chemistry analysis demonstrates an efficient route to apixaban analogues, highlighting practical access to potential anticoagulant candidates.
An alternate synthetic approach has been described to access novel apixaban analogues.The present strategy offers a practical and cost-effective synthetic procedure to construct the privileged scaffold and its amide derivatives that may exhibit promising anticoagulant potency.Moreover, the method was performed by using less expensive reagents, easily achievable precursors, and fewer intermediary steps, providing a good yield of the desired substances.
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Gaikwad et al. (2024) studied this question.
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