High-grade glial cancers typically arise in the cerebral hemisphere and rarely in the cerebellum. Our objective was to highlight the diagnostic features of isocitrate dehydrogenase (IDH)-mutant high-grade gliomas in the cerebellum. We present a case of an elderly patient admitted with giddiness who was diagnosed with IDH-mutant high-grade glioma in the cerebellum, presenting as multiple lesions. We evaluated an open biopsy specimen to arrive at a diagnosis and used molecular studies to confirm the diagnosis and further categorize the specimens. Histopathology and immunohistochemistry confirmed the diagnosis of IDH-mutant high-grade glioma in the cerebellum.
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Dinesh et al. (2024) studied this question.
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