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June 27, 2024Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics of nalbuphine administered intravenously and subcutaneously in goats (Capra aegagrus hircus)

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Authors

JGJessica D. GarciaKnoxville CollegeJSJoe S. SmithSpartanburg Regional Healthcare SystemDMDavid MinichUniversity of Illinois Urbana-Champaign

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Implication

Pharmacokinetic evaluation reveals intravenous and subcutaneous nalbuphine disposition profiles in domestic goats, highlighting plasma concentration time metrics across administration routes.

Key Points

  • Nalbuphine administration demonstrates measurable systemic disposition in domestic goats, providing essential pharmacokinetics data across intravenous and subcutaneous routes.
  • Dosing at 0.8 mg/kg established drug profiles over a 36-hour period in goats, with high-performance liquid chromatography quantifying systemic nalbuphine concentrations.
  • Compartmental and noncompartmental analysis characterizes elimination half-life and drug exposure, supporting tailored nalbuphine analgesia protocols in domestic goats.

Cite This Study

Garcia et al. (2024) studied this question.

synapsesocial.com/papers/68e63126b6db6435875c36a6https://doi.org/10.1111/jvp.13463
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