Towards personalized TSH reference ranges: A genetic and population-based approach in three independent cohorts

This is the authors' abstract. We don't add key points for this paper.

Serum thyroid-stimulating hormone (TSH) measurement is the diagnostic cornerstone for primary thyroid dysfunction. There is high inter-individual but limited intra-individual variation in TSH concentrations, largely due to genetic factors. The currently used wide population-based reference intervals may lead to inappropriate management decisions.