Objectives Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating chronic illness for which there are no well-accepted treatments, aside from some preliminary trials and symptom management strategies, such as low-dose naltrexone and NICE guidelines. A clinician administered a synergistic off-label treatment (SOT) involving spironolactone, colchicine, low-dose naltrexone, and multivitamins to ME/CFS patients, resulting in reported symptom improvement. This study sought to investigate neuroimaging characteristics linked with the treatment.
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Mohamed et al. (2024) studied this question.
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