Site‐Selective Activation and Stereospecific Functionalization of Bis(boronic esters) Derived from 2‐Alkenes: Construction of Propionates and Other 1,2‐Difunctional Motifs

Non‐directed regioselective activation of bis(boronic esters), followed by functionalization, is reported. A bulky activator is shown to selectively activate the less hindered boronic ester enabling it to undergo stereospecific cross‐coupling to a variety of electrophiles. This steric‐based regioselectivity provides a simple and efficient method to prepare highly functionalized, enantiomerically enriched products starting from simple alkenes.