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June 26, 2024Open Access

Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis

Andrew R. Tee R.E. Jones Elaine A. Dunlop Jesse D. Champion Peter F. Doubleday Tijs Claessens Zahra Jalali Sara Seifan Iain Perry Peter Giles Oliver J. Harrison Barry J. Coull Arjan C. Houweling Arnim Pause Bryan A. Ballif

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Abstract

Birt-Hogg-Dubé (BHD) syndrome patients are uniquely susceptible to all renal tumour subtypes. The underlying mechanism of carcinogenesis is unclear. To study cancer development in BHD, we used human proximal kidney (HK2) cells and found that long-term folliculin

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Tee et al. (2024) studied this question.

synapsesocial.com/papers/68e633b3b6db6435875c586a https://doi.org/10.21203/rs.3.rs-4510670/v1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Birt-Hogg-Dubé syndromeOriginal Research · 2026
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