Carbamoylation of azaarenes and olefins with formamides through dual photoredox/HAT catalysis

Among the different methods to synthesize amides, radical amidation of suitable acceptors is appealing. In this context, we have developed a methodology for the photoinduced Minisci and Giese carbamoylation with readily available formamides. This approach avoids using less atom-efficient carbamoyl precursors (e.g., oxamic acids) and sacrificial oxidants, relying on dual photoredox/hydrogen atom transfer (HAT) catalysis.