Electrochemical method demonstrates direct formation of N‐arylamides from α‐keto acids and arylamines, suggesting new pathways in medicinal chemistry.
Amide bonds are ubiquitous in bioactive molecules, yet their synthesis often relies on prefunctionalized reagents or stoichiometric activators, posing sustainability challenges. Herein, we report a novel electrochemical decarboxylative amidation strategy enabling direct coupling of α‐keto acids with arylamines to access N‐arylamides under mild, oxidant‐free conditions. This redox mediator‐controlled indirect electrolysis harnesses ferrocene to facilitate single‐electron oxidation of α‐keto acids, generating acyl radicals that couple with anodically oxidized arylamine radicals to form amides efficiently. This programmable approach offers operational simplicity and synthetic versatility, providing streamlined access to valuable amide scaffolds with promising applications in medicinal chemistry.
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Sa et al. (2025) studied this question.
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