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Review shows pleiotropic benefits of sitagliptin across cardiovascular, renal, and metabolic systems in type 2 diabetes mellitus, highlighting therapeutic applications beyond glycemic control.
Sitagliptin is used to improve glycemic control in patients with type 2 diabetes mellitus. However, modern research is revealing its ability to have significant effects on other systems of the body, going beyond simply managing glucose levels. Sitagliptin can reduce the risk of cardiovascular complications, affect the blood lipid spectrum, and the patient’s weight. Sitagliptin has also been demonstrated to slow the progression of chronic kidney disease. Sitagliptin may slow the progression of liver fibrosis. It may also be useful in treating diseases caused by disorders of the immune system, reproductive system and central nervous system. The review summarizes current information on clinical trials using sitagliptin in different patient cohorts.
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Дыгун et al. (2024) studied this question.
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