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Evaluation observes uncertain transcript reclassification across suspicious lesions in kidney transplant biopsies, suggesting potential limits for automated diagnostics.
Isolated Tubulitis, Borderline Changes, and Isolated Arteritis suspicious for histologic T cell-mediated rejection (hTCMR) remain findings of uncertain significance. Although the Molecular Microscope Diagnostics System (MMDx) has not been trained on those lesions, it was suggested that MMDx might reclassify a subgroup to molecular TCMR (mTCMR).
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Weidmann et al. (2024) studied this question.
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