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Introduction: Smoking is a major risk factor for cardiovascular disease, with a significant impact on platelet activation and thrombosis. This study aims to examine the effects of smoking on platelet activation and INR as a marker of thrombosis. This study aimed to investigate the influence of tobacco smoking on platelets count and coagulation tests (PT, PTT, INR) in adult males in sirte city. Materials and Methods: A case control study was carried out during 1/1/2023 to 15/2/2023. 200 males (100 smokers and 100 non-smokers) were participated in this study. with ages between 15-85 years enrolled in this study. Data were presented in median (interquartile range). Data was collected by using structural interviewing questionnaire. blood samples were collected in tri sodium citrate anti-coagulant for PT and INR, manually analyzed was using. Ethylene-di-amine-tetra-acetic acid (EDTA) anticoagulant for the platelets count, analyzed by (Sysmex, German) automated hematology analyzer. Main Results: The results showed that the Median platelets count was statistically no significantly between smokers (237) and non-smokers (256) , U = 5.696.000 , Z = 1.701, P = 0.089. Whereas, median PT was statistically significant between smokers (15) and non-smokers (14), U = 4.112.000, Z = -2.194 , P = 0.028. Also, median INR was statistically significant between smokers (1.4) and non-smokers (1.3), U = 4.063.500, Z = -2.316 , P = 0.021. Conclusion: The present study shows that smokers likely to have lesser platelet counts , longer PT, and higher INR values in comparable to non-smokers. Thus, smoking might be related with bleeding complaints but additional examinations are required.
ALgmati et al. (Tue,) studied this question.