Murine model demonstrates that MEK1/2 and ERK1/2 activation promotes diffuse alveolar hemorrhage in lupus-prone mice, suggesting kinase-mediated endothelial injury drives pulmonary vasculitis.
About 3% of patients with lupus develop severe diffuse alveolar hemorrhage (DAH) with pulmonary vasculitis. C57BL/6 (B6) mice with pristane-induced lupus also develop DAH, but BALB/c mice are resistant. DAH is independent of Toll-like receptor signaling and other inflammatory pathways. This study examined the role of the MEK1/2 pathway (MEK1/2-ERK1/2, JNK, p38).
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Zhuang et al. (2024) studied this question.
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