Use of postbiotics and salicylic acid in a nanostructured system to control Cutibacterium acnes

For a long time, acne was associated with the proliferation of Cutibacterium acnes (C. acnes). Recently, subgroups of C. acnes have been discovered, suggesting that acne may occur due to a possible dysbiosis among these subgroups. The aim of this study was to analyzes three formulations against acne: salicylic acid (SA) in nanostructured lipid carriers (NLC), lipase in mesoporous silica (SBA-15), and inactivated Lactobacillus acidophilus (LAC-I). The NLC formulation with salicylic acid was characterized for SA content, release, and particle size. The lipase associated with SBA-15 (LIP-SIL) was analyzed for enzymatic activity and preservation over 30 days. LAC-I was obtained by culturing LAC and inactivating it through ultrasonication. In conclusion, it can be said that the strategies proposed in this study were viable for controlling the development of C acnes in an in vitro controlled medium, therefore those strategies must be investigated as alternatives for acne control on human skin.