Formulation Development and Evaluation of Atorvastatin Calcium Extended-Release Tablets

Atorvastatin calcium is an antihyperlipidemic agent that acts as HMG- COA reductase inhibitor. The objectives of the current research are to evaluate Atorvastatin calcium release from sustained-release tablets. FTIR analysis reveals that drug and polymer have no interaction. The tablets were created utilizing the wet granulation process by using various concentrations of polymer like HPMC. The prepared extended-release tablets have been assessed for friability, thickness, drug content, hardness, and in-vitro drug release studies. From the release analysis at high concentrations demonstrate better release than HPMC low concentration. The in-vitro release data findings indicate that HPMC polymer exhibits a better release rate at 18 hours showing 97.63.