Frequency of Delayed Puberty in Boys with Contemporary Management of Duchenne Muscular Dystrophy

What is already known on this topic?Delayed puberty represents a documented clinical outcome associated with the prolonged administration of glucocorticoids in adolescents with Duchenne Muscular Dystrophy (DMD).Nevertheless, there exists a dearth of comprehensive data regarding the prevalence and severity of delayed puberty in individuals affected by DMD. What this study adds?Based on clinical assessments conducted by a paediatric endocrinologist, delayed puberty was observed in a striking 82% of boys with DMD who were receiving daily glucocorticoids.Our findings underscore the critical importance of implementing regular puberty monitoring and managing delayed puberty in adherence to international standards of care.Additionally, these results offer a valuable benchmark for evaluating the efficacy of newer treatment strategies designed to mitigate glucocorticoid-related side effects.