Randomized trial evaluates the feasibility of balanced crystalloid versus albumin resuscitation in hospital sepsis, suggesting a pathway to definitive trials.
International guidelines recommend IV crystalloid as the primary fluid for sepsis resuscitation, with 5% human albumin solution (HAS) as the second line. However, it is unclear which fluid has superior clinical effectiveness. We conducted a trial to assess the feasibility of delivering a randomized controlled trial comparing balanced crystalloid against 5% HAS as sole early resuscitation fluid in patients with sepsis presenting to hospital.
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Gray et al. (2024) studied this question.
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