What question did this study set out to answer?

To examine the comparative effects of different resuscitative fluids on mortality in adult patients presenting with sepsis or septic shock.

July 21, 2014Annals of Internal MedicineOpen Access

Fluid Resuscitation in Sepsis

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To examine the comparative effects of different resuscitative fluids on mortality in adult patients presenting with sepsis or septic shock.
Searched multiple biomedical databases through March 2014 without language restrictions for randomized trials assessing resuscitative fluids in adult sepsis.
Identified and analyzed 14 randomized trials encompassing 18,916 patients across 15 direct comparisons using 4-node and 6-node network meta-analyses.
In the 4-node network meta-analysis, starches led to higher mortality than crystalloids (high confidence), while albumin achieved lower mortality than both crystalloids and starches (moderate confidence).
In the 6-node model, albumin reduced mortality compared with saline (moderate confidence) and low-molecular-weight starch (low confidence), while balanced crystalloids reduced mortality compared with saline (low confidence) and starches (moderate confidence).

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Implication

Network meta-analysis reveals lower mortality with balanced crystalloids and albumin in sepsis patients, indicating superior fluid resuscitation strategies.

Cite This Study

Rochwerg et al. (2014) studied this question.

synapsesocial.com/papers/6a83078ac0477142e551a8c2 https://doi.org/10.7326/m14-0178

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Implication

Network meta-analysis reveals lower mortality with balanced crystalloids and albumin in sepsis patients, indicating superior fluid resuscitation strategies.

Fluid Resuscitation in Sepsis

Key Points

Discussion

Implication

Cite This Study

Fluid Resuscitation in Sepsis

Key Points

Discussion

Implication

Cite This Study

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