Individualized fluid resuscitation for sepsis: A mini review

Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to significant vasodilation and fluid leakage. Early fluid resuscitation is a cornerstone of sepsis management aimed at mitigating relative or absolute deficiencies in circulating blood volume. Despite the establishment of immediate fluid resuscitation upon sepsis recognition, the optimal strategy, type of fluid, and endpoints of resuscitation remain subjects of considerable debate. The heterogeneity of sepsis and its progression complicate the development of a universal resuscitation approach. This article emphasizes the necessity for individualized fluid resuscitation in sepsis, while considering the patient’s disease state, fluid responsiveness, and tolerance. Indeed, it highlights the need to move away from a one-size-fits-all strategy to a more personalized care plan. The choice of fluid type, whether crystalloids or albumin, should be tailored to the patient’s specific needs and risk factors. Continuous dynamic assessment is key to optimizing fluid therapy and maximizing patient benefit while minimizing potential risks.