Clinical efficacy of various resuscitation fluids in the management of sepsis in postoperative surgical and trauma patients: a systematic review and meta-analysis

META-ANALYSIS General surgery Sepsis and fluid therapy 275 are subject to significant practice variations. 5,6Clinical research has demonstrated that colloids and crystalloids have a distinct impact on a variety of critical physiological parameters.Fluid categories for the purpose of fluid resuscitation include blood products, colloids (eg, albumin, gelatin solutions, and hydroxyethyl starch [HES]), and crystalloids, including normal saline (NS) and Ringer's lactate. 7-9Studies examining clinical outcomes of fluid resuscitation have reported reduced length of hospital stay, decreased mortality, INTRODUCTION Fluid resuscitation is the primary management strategy for critically hypotensive patients, and it has played a significant role in reducing mortality over the years. 1,2Research indicates that early fluid resuscitation effectively prevents and restricts sepsis, inhibits prevalent multiorgan failure, improves microcirculation, and reduces the systemic inflammatory response. 3,4Fluids are a fundamental component of resuscitation of critically hypotensive patients; however, fluid management strategies